CHCHD6 anticorps (N-Term)

N° du produit ABIN6991790

Détail du produit anti-CHCHD6 anticorps

Antigène: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Épitope: AA 20-70, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHCHD6 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CHCHD6 is predicted to not cross-react to other members of the CHCHD family.

Purification: CHCHD6 Antibody is affinity chromatography purified via peptide column.

Immunogène: Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6.

Isotype: IgG

Information d'application

Indications d'application: CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CHCHD6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CHCHD6

Antigène: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Autre désignation: CHCHD6 (CHCHD6 Produits)

Synonymes: anticorps CHCM1, anticorps PPP1R23, anticorps 0710001P09Rik, anticorps 1700021B03Rik, anticorps chchd6, anticorps hm:zeh0124, anticorps zgc:91802, anticorps coiled-coil-helix-coiled-coil-helix domain containing 6, anticorps coiled-coil-helix-coiled-coil-helix domain containing 6a, anticorps CHCHD6, anticorps Chchd6, anticorps chchd6a

Sujet: CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Poids moléculaire: Predicted: 26 kDa

ID gène: 84303

NCBI Accession: NP_115719

UniProt: Q9BRQ6