CISD2 anticorps (AA 40-90)

N° du produit ABIN6991848

Cet anticorps anti-CISD2 est un anticorps Lapin Polyclonal détectant CISD2 dans WB, ELISA, IF et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CISD2 anticorps (AA 40-90) (ABIN6991848)

Antigène: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CISD2 anticorps

Épitope: AA 40-90

Purification: CISD2 Antibody is affinity chromatography purified via peptide column.

Immunogène: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2. The immunogen is located within amino acids 40 - 90 of CISD2.

Isotype: IgG

Information d'application

Indications d'application: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CISD2

Antigène: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Autre désignation: CISD2

Sujet: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Poids moléculaire: Predicted: 15 kDa

Observed: 15 kDa

ID gène: 493856

NCBI Accession: NP_001008389

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response