CRTC2 anticorps (C-Term)

N° du produit ABIN6991855

Cet anticorps Lapin Polyclonal détecte spécifiquement CRTC2 dans WB, ELISA, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CRTC2 anticorps (C-Term) (ABIN6991855)

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRTC2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CRTC2 anticorps

Épitope: C-Term

Specificité: Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.

Purification: CRTC2 Antibody is affinity chromatography purified via peptide column.

Immunogène: CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2. The immunogen is located within the last 50 amino acids of CRTC2.

Isotype: IgG

Information d'application

Indications d'application: CRTC2 antibody can be used for detection of CRTC2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRTC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CRTC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur CRTC2

Antigène: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Autre désignation: CRTC2

Sujet: CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.

Poids moléculaire: Predicted: 67, 76 kDa

Observed: 70 kDa

ID gène: 200186

NCBI Accession: NP_859066

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis