DIS3 anticorps (N-Term)

N° du produit ABIN6991861

Cet anticorps Lapin Polyclonal détecte spécifiquement DIS3 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour DIS3 anticorps (N-Term) (ABIN6991861)

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-DIS3 anticorps

Épitope: AA 90-140, N-Term

Specificité: Multiple isoforms of DIS3 are known to exist.

Purification: DIS3 Antibody is affinity chromatography purified via peptide column.

Immunogène: DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.

Isotype: IgG

Information d'application

Indications d'application: DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DIS3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur DIS3

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Autre désignation: DIS3

Sujet: DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Poids moléculaire: Predicted: 105 kDa

Observed: 103 kDa

ID gène: 22894

NCBI Accession: NP_055768

UniProt: Q9Y2L1