RNF20 anticorps (N-Term)

N° du produit ABIN6991864

Cet anticorps Lapin Polyclonal détecte spécifiquement RNF20 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour RNF20 anticorps (N-Term) (ABIN6991864)

Antigène: RNF20 (Ring Finger Protein 20 (RNF20))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF20 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RNF20 anticorps

Épitope: AA 130-180, N-Term

Specificité: Multiple isoforms of RNF20 are known to exist.

Purification: RNF20 Antibody is affinity chromatography purified via peptide column.

Immunogène: RNF20 antibody was raised against a 19 amino acid peptide near the amino terminus of human RNF20. The immunogen is located within amino acids 130 - 180 of RNF20.

Isotype: IgG

Information d'application

Indications d'application: RNF20 antibody can be used for detection of RNF20 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: RNF20 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: RNF20 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur RNF20

Antigène: RNF20 (Ring Finger Protein 20 (RNF20))

Autre désignation: RNF20

Sujet: RNF20 Antibody: RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Poids moléculaire: Predicted: 99, 107 kDa

Observed: 100, 110 kDa

ID gène: 56254

NCBI Accession: NP_062538

UniProt: Q5VTR2