DAP anticorps (C-Term)

N° du produit ABIN6991874

L’anticorps Lapin Polyclonal anti-DAP a été validé pour ELISA, WB, IF et IHC (p). Il convient pour détecter DAP dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour DAP anticorps (C-Term) (ABIN6991874)

Antigène: DAP (Death-Associated Protein (DAP))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DAP est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-DAP anticorps

Épitope: C-Term

Specificité: DAP antibody is human, mouse and rat reactive.

Purification: DAP Antibody is affinity chromatography purified via peptide column.

Immunogène: DAP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DAP. The immunogen is located within the last 50 amino acids of DAP.

Isotype: IgG

Information d'application

Indications d'application: DAP antibody can be used for detection of DAP by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur DAP

Antigène: DAP (Death-Associated Protein (DAP))

Autre désignation: DAP

Sujet: DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15 kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51, under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).

Poids moléculaire: Predicted: 11 kDa

Observed: 11 kDa

ID gène: 1611

NCBI Accession: NP_004385

UniProt: P51397

Pathways: Positive Regulation of Endopeptidase Activity, Feeding Behaviour