MFN1 anticorps (N-Term)

N° du produit ABIN6992021

L’anticorps Lapin Polyclonal anti-MFN1 a été validé pour WB, ELISA et ICC. Il convient pour détecter MFN1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MFN1 anticorps (N-Term) (ABIN6992021)

Antigène: MFN1 (Mitofusin 1 (MFN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-MFN1 anticorps

Épitope: AA 20-70, N-Term

Specificité: MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.

Purification: MFN1 antibody is affinity chromatography purified via peptide column.

Immunogène: MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1. The immunogen is located within amino acids 20 - 70 of MFN1.

Isotype: IgG

Information d'application

Indications d'application: MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MFN1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MFN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur MFN1

Antigène: MFN1 (Mitofusin 1 (MFN1))

Autre désignation: MFN1

Sujet: Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).

Poids moléculaire: Predicted: 82 kDa

Observed: 83 kDa

ID gène: 55669

NCBI Accession: NP_284941

UniProt: Q8IWA4