IQSEC1 anticorps (N-Term)

N° du produit ABIN6992076

Cet anticorps anti-IQSEC1 est un anticorps Lapin Polyclonal détectant IQSEC1 dans WB, ELISA, ICC et IF. Adapté pour Souris, Humain et Rat.

Aperçu rapide pour IQSEC1 anticorps (N-Term) (ABIN6992076)

Antigène: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IQSEC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-IQSEC1 anticorps

Épitope: AA 60-110, N-Term

Specificité: IQSEC1 antibody is human, mouse and rat reactive. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is predicted to not cross-react with IQSEC2.

Purification: IQSEC1 antibody is affinity chromatography purified via peptide column.

Immunogène: IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1. The immunogen is located within amino acids 60 - 110 of IQSEC1.

Isotype: IgG

Information d'application

Indications d'application: IQSEC1 antibody can be used for detection of IQSEC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 2 μ,g/mL. For immunofluorescence start at 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IQSEC1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IQSEC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IQSEC1

Antigène: IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))

Autre désignation: IQSEC1

Sujet: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4).

Poids moléculaire: Predicted: 106 kDa

Observed: 103 kDa

ID gène: 9922

NCBI Accession: NP_055684

UniProt: Q6DN90