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JAGN1 anticorps (C-Term)

JAGN1 Reactivité: Humain, Souris, Rat ELISA, WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6992170
  • Antigène Voir toutes JAGN1 Anticorps
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Épitope
    C-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 5
    Lapin
    Clonalité
    • 5
    Polyclonal
    Conjugué
    • 2
    • 1
    • 1
    • 1
    Cet anticorp JAGN1 est non-conjugé
    Application
    • 4
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist, this antibody will detect all but isoform 2.
    Purification
    JAGN1 antibody is affinity chromatography purified via peptide column.
    Immunogène
    JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1. The immunogen is located within the last 50 amino acids of JAGN1.
    Isotype
    IgG
    Top Product
    Discover our top product JAGN1 Anticorps primaire
  • Indications d'application
    JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    JAGN1 antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    JAGN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Antigène
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Autre désignation
    JAGN1 (JAGN1 Produits)
    Synonymes
    anticorps GL009, anticorps 5830427H10Rik, anticorps zgc:101070, anticorps wu:fb07b07, anticorps zgc:101045, anticorps jagunal homolog 1, anticorps jagunal homolog 1 L homeolog, anticorps jagunal homolog 1a, anticorps jagunal homolog 1b, anticorps JAGN1, anticorps Jagn1, anticorps jagn1.L, anticorps jagn1a, anticorps jagn1b
    Sujet
    JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).
    Poids moléculaire
    Predicted: 20 kDa

    Observed: 25 kDa
    ID gène
    84522
    NCBI Accession
    NP_115881
    UniProt
    Q8N5M9
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