BCLAF1 anticorps (C-Term)

N° du produit ABIN6992173

Cet anticorps Lapin Polyclonal détecte spécifiquement BCLAF1 dans WB, ELISA et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BCLAF1 anticorps (C-Term) (ABIN6992173)

Antigène: BCLAF1 (BCL2-Associated Transcription Factor 1 (BCLAF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCLAF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BCLAF1 anticorps

Épitope: AA 820-870, C-Term

Specificité: BCLAF1 antibody is human, mouse and rat reactive. At least four isoforms of BCLAF1 are known to exist, this antibody will detect all but isoform 2.

Purification: BCLAF1 antibody is affinity chromatography purified via peptide column.

Immunogène: BCLAF1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human BCLAF1. The immunogen is located within amino acids 820 - 870 of BCLAF1.

Isotype: IgG

Information d'application

Indications d'application: BCLAF1 antibody can be used for detection of BCLAF1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: BCLAF1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: BCLAF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur BCLAF1

Antigène: BCLAF1 (BCL2-Associated Transcription Factor 1 (BCLAF1))

Autre désignation: BCLAF1

Sujet: The BCL2-associated transcription factor 1 (BCLAF1) is a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins (1). BCLAF1 localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. (2). More recent studies have suggested BCLAF1 plays roles in processes not associated with actions of the BCL2 family members, including lung development, T cell activation, and post-transcriptional processes that affect mRNA metabolism (3).

Poids moléculaire: Predicted: 101 kDa

Observed: 105 kDa

ID gène: 9774

NCBI Accession: NP_055554

UniProt: Q9NYF8

Pathways: Positive Regulation of Response to DNA Damage Stimulus