Vinculin anticorps (N-Term) (Biotin)

N° du produit ABIN6992215

Cet anticorps Lapin Polyclonal détecte spécifiquement Vinculin dans WB et ELISA. Il présente une réactivité envers Humain, Souris, Rat, Lapin et Poulet.

Aperçu rapide pour Vinculin anticorps (N-Term) (Biotin) (ABIN6992215)

Antigène: Vinculin (VCL)

Reactivité: Humain, Souris, Rat, Lapin, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Vinculin est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA

Détail du produit anti-Vinculin anticorps (Biotin)

Épitope: N-Term

Specificité: Biotin-Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

Purification: Biotin-Vinculin antibody is affinity chromatography purified via peptide column.

Immunogène: Biotin-Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.

Isotype: IgG

Information d'application

Indications d'application: Vinculin antibody can be used for detection of Vinculin by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Biotin-Vinculin Antibody is supplied in PBS containing 1 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Biotin-Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur Vinculin

Antigène: Vinculin (VCL)

Autre désignation: Vinculin

Sujet: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).

Poids moléculaire: Predicted: 117 kDa

Observed: 117 kDa

ID gène: 7414

NCBI Accession: NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2