PD-1 anticorps (Extracellular Domain) (Biotin)

N° du produit ABIN6992219

L’anticorps Souris Monoclonal anti-PD-1 a été validé pour ELISA. Il convient pour détecter PD-1 dans des échantillons de Humain.

Aperçu rapide pour PD-1 anticorps (Extracellular Domain) (Biotin) (ABIN6992219)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est conjugé à/à la Biotin

Application: ELISA

Clone: 7H6

Détail du produit anti-PD-1 anticorps (Biotin)

Épitope: Extracellular Domain

Purification: PD-1 Antibody (biotin) is supplied as protein A purified IgG1.

Immunogène: PD-1 antibody (biotin) was raised against the extracellular domain of human PD-1.

Isotype: IgG1

Information d'application

Indications d'application: PD1 antibody can be used for as detection antibody in Sandwich Elisa at 1 μ,g/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PD-1 Antibody (biotin) is supplied in PBS containing 1 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PD-1 Antibody (biotin) can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: PD1

Sujet: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

ID gène: 5133

NCBI Accession: NP_005009

UniProt: Q15116

Pathways: Cancer Immune Checkpoints