Hsp40 (chaperone DnaJ) anticorps

N° du produit ABIN7237214

L’anticorps anti-Hsp40 (chaperone DnaJ) Polyclonal Lapin est utilisé pour la détection de Hsp40 (chaperone DnaJ) dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC, ELISA et WB.

Aperçu rapide pour Hsp40 (chaperone DnaJ) anticorps (ABIN7237214)

Antigène: Hsp40 (chaperone DnaJ)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Détail du produit

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant protein of human DNAJA1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: Hsp40 (chaperone DnaJ)

Autre désignation: HSP40-4

Sujet: DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Poids moléculaire: 45 kDa

UniProt: P31689