SMAD7 anticorps

N° du produit ABIN7242434

L’anticorps anti-SMAD7 Polyclonal Lapin est utilisé pour la détection de SMAD7 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et IHC.

Aperçu rapide pour SMAD7 anticorps (ABIN7242434)

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD7 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SMAD7 anticorps

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthetic peptide of human SMAD7

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMAD7

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Autre désignation: SMAD7

Sujet: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

NCBI Accession: NP_005895

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization