MOB2 anticorps

N° du produit ABIN7248908

Détail du produit anti-MOB2 anticorps

Antigène: MOB2 (MOB Kinase Activator 2 (MOB2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MOB2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human MOB2

Isotype: IgG

Information d'application

Indications d'application: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.08 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MOB2

Antigène: MOB2 (MOB Kinase Activator 2 (MOB2))

Autre désignation: MOB2 (MOB2 Produits)

Synonymes: anticorps HCCA2, anticorps 1110017M21Rik, anticorps 2700078K21Rik, anticorps AI256456, anticorps Mmh, anticorps Hcca2, anticorps RGD1562983, anticorps hcca2, anticorps mob2, anticorps mob2.1, anticorps p5a5, anticorps Mob2, anticorps MOB kinase activator 2, anticorps MOB kinase activator 2 L homeolog, anticorps multigenic obesity QTL 2, anticorps MOB2, anticorps Mob2, anticorps mob2.1.L, anticorps Mobq2

Sujet: MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

UniProt: Q70IA6