NBR1 anticorps

N° du produit ABIN7250371

Cet anticorps anti-NBR1 est un anticorps Souris Monoclonal détectant NBR1 dans IF et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour NBR1 anticorps (ABIN7250371)

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NBR1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4C6

Détail du produit anti-NBR1 anticorps

Attributs du produit: Monoclonal Antibody

Purification: Protein A purification

Immunogène: Recombinant Protein of NBR1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-300, IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NBR1

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Autre désignation: NBR1

Sujet: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProt: Q14596

Pathways: Autophagy