FKBPL anticorps

N° du produit ABIN7252003

Détail du produit anti-FKBPL anticorps

Antigène: FKBPL (FK506 Binding Protein Like (FKBPL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FKBPL est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human FKBPL

Isotype: IgG

Information d'application

Indications d'application: IHC 1:30-1:150, ELISA 1:2000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.3 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FKBPL

Antigène: FKBPL (FK506 Binding Protein Like (FKBPL))

Autre désignation: FKBPL (FKBPL Produits)

Synonymes: anticorps FKBPL, anticorps ng7, anticorps dir1, anticorps wisp39, anticorps DIR1, anticorps NG7, anticorps WISP39, anticorps Ppiase-X, anticorps Wisp39, anticorps FK506 binding protein like, anticorps FK506 binding protein-like, anticorps FKBPL, anticorps fkbpl, anticorps Fkbpl

Sujet: FKBPL,also named as DIR1,NG7 and WISp39,has similarity to the immunophilin protein family,which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance,probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant,whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 Molecular complexes, furthermore,FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.

UniProt: Q9UIM3