SETDB1 anticorps

N° du produit ABIN7253431

L’anticorps Lapin Polyclonal anti-SETDB1 a été validé pour ELISA et IHC. Il convient pour détecter SETDB1 dans des échantillons de Humain et Souris.

Aperçu rapide pour SETDB1 anticorps (ABIN7253431)

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETDB1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SETDB1 anticorps

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human SETDB1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.08 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SETDB1

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Autre désignation: SETDB1

Sujet: SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.

UniProt: Q15047