ERH anticorps

N° du produit ABIN7253677

Détail du produit anti-ERH anticorps

Antigène: ERH (Enhancer of Rudimentary Homolog (ERH))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERH est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human ERH

Isotype: IgG

Information d'application

Indications d'application: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ERH

Antigène: ERH (Enhancer of Rudimentary Homolog (ERH))

Autre désignation: ERH (ERH Produits)

Synonymes: anticorps ERH, anticorps erha, anticorps e(r), anticorps DROER, anticorps Mer, anticorps Prei1, anticorps zgc:86761, anticorps enhancer of rudimentary homolog (Drosophila), anticorps enhancer of rudimentary homolog, anticorps ERH, mRNA splicing and mitosis factor S homeolog, anticorps ERH, mRNA splicing and mitosis factor, anticorps ERH, anticorps erh.S, anticorps Bm1_07775, anticorps LOC100634139, anticorps LOC100643325, anticorps Erh, anticorps erh

Sujet: ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes. ERH may play a role in cell cycle regulation and pyrimidine biosynthesis. ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1). HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD. By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver. The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands. ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH. ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dimerize.

UniProt: P84090