F13A1 anticorps
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- Antigène Voir toutes F13A1 Anticorps
- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp F13A1 est non-conjugé
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Application
- Western Blotting (WB)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human F13A1 (NP_000120.2).
- Isotype
- IgG
- Top Product
- Discover our top product F13A1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
- Autre désignation
- F13A1 (F13A1 Produits)
- Synonymes
- anticorps F13a, anticorps f13a1, anticorps wu:fo83d04, anticorps zgc:153334, anticorps F13A1, anticorps F13A, anticorps 1200014I03Rik, anticorps AI462306, anticorps coagulation factor XIII A1 chain, anticorps coagulation factor XIII, A1 polypeptide b, anticorps coagulation factor XIII A chain, anticorps coagulation factor XIII, A1 subunit, anticorps F13a1, anticorps f13a1b, anticorps F13A1
- Sujet
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
- Poids moléculaire
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Observed_MW: 83 kDa
Calculated_MW: 83 kDa
- ID gène
- 2162
- UniProt
- P00488
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