HMGCS1 anticorps

N° du produit ABIN7260905

Détail du produit anti-HMGCS1 anticorps

Antigène: HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGCS1 est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human HMGCS1 (NP_002121.4).

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HMGCS1

Antigène: HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))

Autre désignation: HMGCS1 (HMGCS1 Produits)

Synonymes: anticorps HMGCS, anticorps zgc:56481, anticorps B130032C06Rik, anticorps 3-hydroxy-3-methylglutaryl-CoA synthase 1, anticorps 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble), anticorps 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, anticorps 3-hydroxy-3-methylglutaryl coenzyme A synthase, anticorps hydroxymethylglutaryl-CoA synthase, anticorps 3-hydroxy-3-methylglutaryl-CoA synthase, anticorps hydroxymethylglutaryl coenzyme A synthase, anticorps 3-hydroxy-3-methylglutaryl-CoA synthase 1 S homeolog, anticorps HMGCS1, anticorps hmgcs1, anticorps Hmgcs1, anticorps mvaS, anticorps SAS2432, anticorps SZO_RS04705, anticorps SEQ_1109, anticorps NAEGRDRAFT_77778, anticorps hmgcs1.S

Sujet: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

ID gène: 3157

UniProt: Q01581

Pathways: Regulation of Lipid Metabolism by PPARalpha