IREB2 anticorps

N° du produit ABIN7262188

Détail du produit anti-IREB2 anticorps

Antigène: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IREB2 est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human IREB2 (NP_004127.1).

Isotype: IgG

Information d'application

Indications d'application: IF 1:20-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IREB2

Antigène: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Autre désignation: IREB2 (IREB2 Produits)

Synonymes: anticorps IREB2, anticorps im:7153062, anticorps DKFZp468N047, anticorps D9Ertd85e, anticorps Irp2, anticorps ACO3, anticorps IRP2, anticorps IRP2AD, anticorps IREBP2, anticorps iron responsive element binding protein 2, anticorps iron-responsive element binding protein 2, anticorps iron responsive element binding protein 2 L homeolog, anticorps IREB2, anticorps ireb2, anticorps Ireb2, anticorps ireb2.L

Sujet: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms.

ID gène: 3658

UniProt: P48200

Pathways: Transition Metal Ion Homeostasis