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PIKFYVE anticorps

PIKFYVE Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7011299
  • Antigène Voir toutes PIKFYVE Anticorps
    PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 29
    • 4
    • 2
    Lapin
    Clonalité
    • 33
    • 2
    Polyclonal
    Conjugué
    • 23
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIKFYVE est non-conjugé
    Application
    • 23
    • 21
    • 13
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human PIKFYVE (NP_689884.1).
    Isotype
    IgG
    Top Product
    Discover our top product PIKFYVE Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:100 IF 1:10-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))
    Autre désignation
    PIKFYVE (PIKFYVE Produits)
    Synonymes
    anticorps pip5k3, anticorps wu:fo93c03, anticorps PIP5K3, anticorps fab1-like, anticorps CFD, anticorps FAB1, anticorps PIP5K, anticorps ZFYVE29, anticorps 5230400C17Rik, anticorps Pip5k, anticorps Pip5k3, anticorps Pipk5k3, anticorps PipkIII, anticorps p235, anticorps phosphoinositide kinase, FYVE finger containing, anticorps phosphoinositide kinase, FYVE-type zinc finger containing, anticorps phosphoinositide kinase, FYVE type zinc finger containing, anticorps pikfyve, anticorps PIKFYVE, anticorps Pikfyve
    Sujet
    Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve, also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD), an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Poids moléculaire

    Observed_MW: 280 kDa

    Calculated_MW: 50 kDa/51 kDa/61 kDa/237 kDa

    ID gène
    200576
    UniProt
    Q9Y2I7
    Pathways
    Inositol Metabolic Process
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