NEDD4-2 anticorps

N° du produit ABIN7264127

Détail du produit anti-NEDD4-2 anticorps

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEDD4-2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human NEDD4L (NP_056092.2).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NEDD4-2

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Autre désignation: NEDD4L (NEDD4L Produits)

Synonymes: anticorps NEDD4-2, anticorps NEDD4.2, anticorps RSP5, anticorps hNEDD4-2, anticorps nedd4, anticorps nedd4-2, anticorps NEDD4, anticorps Nedd4-2, anticorps 1300012C07Rik, anticorps Nedd4b, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, anticorps NEDD4L, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog, anticorps neural precursor cell expressed, developmentally down-regulated gene 4-like, anticorps NEDD4L, anticorps LOC776799, anticorps nedd4l.S, anticorps Nedd4l

Sujet: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

ID gène: 23327

UniProt: Q96PU5

Pathways: Negative Regulation of Transporter Activity