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STRA13 anticorps

STRA13 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7264936
  • Antigène Voir toutes STRA13 Anticorps
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Reactivité
    Humain
    Hôte
    • 6
    Lapin
    Clonalité
    • 6
    Polyclonal
    Conjugué
    • 3
    • 1
    • 1
    • 1
    Cet anticorp STRA13 est non-conjugé
    Application
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human STRA13 (NP_659435.2).
    Isotype
    IgG
  • Indications d'application
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Autre désignation
    STRA13 (STRA13 Produits)
    Synonymes
    anticorps CENP-X, anticorps CENPX, anticorps D9, anticorps FAAP10, anticorps MHF2, anticorps BHLHB2, anticorps centromere protein X, anticorps CENPX, anticorps Cenpx
    Sujet
    DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
    Poids moléculaire

    Observed_MW: 14 kDa

    Calculated_MW: 6 kDa/7 kDa/8 kDa

    ID gène
    201254
    UniProt
    A8MT69
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