ULK1 anticorps (AA 951-1050)

N° du produit ABIN701440

Détail du produit anti-ULK1 anticorps

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Épitope: AA 951-1050

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK1 est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ATG1/ULK1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ULK1 (ABIN701440)

Shen, Hou, Zhu, Zhao, Ouyang, Feng et al.: "Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion ..." dans: Journal of neurochemistry, Vol. 140, Issue 5, pp. 799-813, (2016) (PubMed).

Gao, Wang, Yi, Kou, Xie, Song: "Activation of lysosomal degradative pathway in spinal cord tissues of carbon disulfide-treated rats." dans: Chemico-biological interactions, Vol. 219C, pp. 76-82, (2014) (PubMed).

Song, Kou, Zou, Gao, Zeng, Xie: "Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens." dans: Neurochemistry international, Vol. 64, pp. 1-8, (2013) (PubMed).

Détails sur ULK1

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Autre désignation: ATG1/ULK1 (ULK1 Produits)

Synonymes: anticorps ATG1, anticorps ATG1A, anticorps UNC51, anticorps Unc51.1, anticorps hATG1, anticorps si:dkey-11o18.7, anticorps ulk1, anticorps ULK1, anticorps AU041434, anticorps mKIAA0722, anticorps zgc:195008, anticorps unc-51 like autophagy activating kinase 1, anticorps unc-51 like kinase 1, anticorps unc-51 like autophagy activating kinase 1a, anticorps ULK1, anticorps Ulk1, anticorps ulk1b, anticorps ulk1a

Sujet:

Synonyms: ATG1, ATG1A, UNC51, hATG1, Unc51.1, Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, Unc-51-like kinase 1, ULK1, KIAA722

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

ID gène: 8408

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy