AQP3 anticorps (C-Term, Intracellular)

N° du produit ABIN7887070

L’anticorps anti-AQP3 Polyclonal Lapin est utilisé pour la détection de AQP3 dans des échantillons de Rat. Il a été validé pour WB, IHC, IF, IP et FACS.

Aperçu rapide pour AQP3 anticorps (C-Term, Intracellular) (ABIN7887070)

Antigène: AQP3 (Aquaporin 3 (Gill Blood Group) (AQP3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AQP3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS)

Classe de qualité: KO Validated

Détail du produit anti-AQP3 anticorps

Épitope: AA 275-292, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Aquaporin 3 Channel

Réactivité croisée: Humain, Souris, Rat

Homologie: 18 amino acid residues identical, sheep,human - 15,Mouse - 17

Attributs du produit: Anti-Aquaporin 3 Antibody (ABIN7042937, ABIN7045198 and ABIN7045199) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, indirect flow cytometry, and immunohistochemistry applications. It has been designed to recognize the AQP3 channel from rat, human, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)STEAENVKLAHMKHKEQI, corresponding to amino acid residues 275-292 of rat AQP3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC|IFC

Negative Control: (ABIN7234763)

Blocking Peptide: (ABIN7234763)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur AQP3

Antigène: AQP3 (Aquaporin 3 (Gill Blood Group) (AQP3))

Autre désignation: AQP3

Sujet:

Synonyms: AQP3, Aquaglyceroporin-3, GIL, GLIP

Description: Aquaporin 3 (AQP-3) belongs to a family of membrane proteins that allow the passage of water and certain other solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3 as well as AQP-7, AQP-9 and AQP-10.1 Little is known about the function of the two newest members, AQP-11 and AQP-12. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.1AQP-3 is widely expressed in several organs with prominent expression found in the skin, colon, lung and kidney. Consistent with a central function of AQP-3 in skin, mice deficient in AQP-3 have reduced skin water content and elasticity compared with wild-type mice, as well as impaired wound healing and epidermal biosynthesis.2 Furthermore, AQP-3 deficient mice were found to be resistant to skin tumor development suggesting a role for this aquaporin in tumorigenesis.3

ID gène: 65133

NCBI Accession: NM_004925

UniProt: P47862