Aquaporin 4 anticorps (C-Term, Intracellular)

N° du produit ABIN7887078

Cet anticorps Lapin Polyclonal détecte spécifiquement Aquaporin 4 dans WB, IHC, IF et IC. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour Aquaporin 4 anticorps (C-Term, Intracellular) (ABIN7887078)

Antigène: Aquaporin 4 (AQP4)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Détail du produit anti-Aquaporin 4 anticorps

Épitope: AA 300-314, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Aquaporin 4 Channel

Réactivité croisée: Souris, Rat

Homologie: human - 13,15 amino acid residues identical,Mouse - 14

Attributs du produit: Anti-Aquaporin 4 (AQP4) (300-314) Antibody (ABIN7042939, ABIN7045209 and ABIN7045210) is a highly specific antibody directed against an epitope of rat AQP4. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize the Aquaporin 4 channel from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HVIDIDRGDEKKGKD, corresponding to amino acid residues 300-314 of rat AQP4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:200

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Aquaporin 4

Antigène: Aquaporin 4 (AQP4)

Autre désignation: AQP4

Sujet:

Synonyms: WCH4, Mercurial-insensitive water channel

Description: Aquaporin 4 (AQP-4) belongs to a family of membrane proteins that allow passage of water and certain solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. AQP-4 together with AQP-1, AQP-2 and AQP-5 belong to the first group1. Little is known about the function of the two newest members, AQP-11 and AQP-12.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1.AQP-4 is the major membrane water channel in the central nervous system. The channel is expressed in astrocyte foot processes in direct contact with capillary vessels in the brain suggesting a role in water transport under normal and pathological conditions. Indeed, transgenic mice lacking AQP-4 have reduced brain swelling and improved neurological outcome following water intoxication and focal cerebral ischemia. In contrast, brain swelling and clinical outcome are worse in AQP-4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP-4-dependent brain water clearance2.In addition, it has been recently shown that neuromyelitis optica (NMO), an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord, is caused by the development of an autoantibody directed against AQP-43.

ID gène: 25293

UniProt: P47863

Pathways: Sensory Perception of Sound