Aquaporin 8 anticorps (Intracellular, N-Term)

N° du produit ABIN7042944

Cet anticorps anti-Aquaporin 8 Polyclonal Lapin (ABIN7042944) détecte spécifiquement Aquaporin 8 dans WB et IHC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour Aquaporin 8 anticorps (Intracellular, N-Term) (ABIN7042944)

Antigène: Aquaporin 8 (AQP8)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aquaporin 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Aquaporin 8 anticorps

Épitope: AA 14-28, Intracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Aquaporin 8 Channel

Homologie: Unlikely to recognize mouse,human samples

Attributs du produit: Anti-Aquaporin 8 Antibody (ABIN7042944 and ABIN7045205) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize AQP8 from rat samples only.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)REIKGKETNMADSYH, corresponding to amino acid residues 14-28 of rat AQP8

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7234779)

Blocking Peptide: (ABIN7234779)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Aquaporin 8

Antigène: Aquaporin 8 (AQP8)

Autre désignation: AQP8

Sujet:

Synonyms: AQP8

Description: Aquaporin 8 (AQP-8) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes.1 The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12.The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are permeated primarily by water and include besides AQP-8, AQP-1, AQP-2, AQP4 and AQP-5, and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3, AQP-7, AQP-9 and AQP-10.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.2AQP-8 is expressed along the gastrointestinal tract including small intestine, colon, pancreas and liver and also in other organs such as testis, lung and kidney.The physiological function of AQP-8 is not entirely clear but studies suggest that it has an important role in colonic water adsorption and hepatocyte bile formation.3,4 Interestingly, AQP-8 expression is markedly altered in gastrointestinal disorders such as ulcerative colitis and inflammatory bowel disease.5

ID gène: 29172

NCBI Accession: NM_001169

UniProt: P56405