AVPR1B anticorps (Intracellular)

N° du produit ABIN7042947

Cet anticorps anti-AVPR1B est un anticorps Lapin Polyclonal détectant AVPR1B dans WB. Adapté pour Rat.

Aperçu rapide pour AVPR1B anticorps (Intracellular) (ABIN7042947)

Antigène: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVPR1B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AVPR1B anticorps

Épitope: AA 399-412, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Vasopressin V1B Receptor

Specificité: Intracellular, C-terminus

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Not recommended for human samples.

Homologie: Mouse - 12,14 amino acid residues identical, human - not recommended for use with human sample

Attributs du produit: Anti-Vasopressin V1B Receptor (AVPR1B) Antibody is directed against an epitope of rat Arginine vasopressin receptor 1B. Anti-Vasopressin V1B Receptor (AVPR1B) Antibody (ABIN7042947, ABIN7045337 and ABIN7045338) can be used in western blot analysis. It has been designed to recognize V1bR from rat and mouse samples. The antibody is not recommended for human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RAKPRPAGSLKDLE, corresponding to amino acid residues 399-412 of rat AVPR1B

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7234790)

Blocking Peptide: (ABIN7234790)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur AVPR1B

Antigène: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Autre désignation: AVPR1B

Sujet: V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Arginine vasopressin receptor 1B, Vasopressin V3 receptor,Vasopressin V1b receptor (also called V3R) is a G protein-coupled receptor (GPCR) of the Gq type, thus activating the phospholipase C signaling pathway upon activation. It is part of a family of GPCRs triggered by vasopressin that further include V1R, V2R, oxytocin receptors and purinergic receptors. While V1R and V3R are Gq GPCRs, V2R is coupled to the Gs protein and activates adenylate cyclase1,2.The V1b receptor has an intracellular C-terminal, seven transmembrane domains, and an extracellular N-tail, the transmembrane and extracellular domains are responsible for interacting with agonists and to signal for activation of the coupled Gq receptor1,2.The V1b receptor is mainly detected in the corticotrophs of the anterior pituitary gland in the brain where it regulates the release of adrenocorticotrophic hormone (ACTH) upon stimulation of vasopressin-corticotrophin-releasing hormone conjugates2.V1b KO mice show that the receptor is critical for the functionality of the hypothalamic-pituitary-adrenal axis, and demonstrate its importance in regulating glucose levels. Recent studies have also suggested that lactating rats treated with V1b antagonists, were less nurturing and similarly aggressive compared with untreated rats and that mice with reduced expression of V1b and V1a receptors have shown resistance to jet-lag1,3,4.

Alternative names: Vasopressin V1B Receptor (AVPR1B), V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Arginine vasopressin receptor 1B, Vasopressin V3 receptor

ID gène: 100909648

NCBI Accession: NM_000707

UniProt: P48974

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones