Astrotactin 1 (ASTN1) (AA 1068-1080), (C-Term), (Extracellular) anticorps

N° du produit ABIN7042949

L’anticorps anti-Astrotactin 1 Polyclonal Lapin est utilisé pour la détection de Astrotactin 1 dans des échantillons de Souris. Il a été validé pour WB, IF et IHC.

Aperçu rapide pour Astrotactin 1 (ASTN1) (AA 1068-1080), (C-Term), (Extracellular) anticorps (ABIN7042949)

Antigène: Astrotactin 1 (ASTN1)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit

Épitope: AA 1068-1080, C-Term, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Astrotactin-1

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,human - identical

Attributs du produit: Anti-ASTN1 (extracellular) Antibody (ABIN7042949, ABIN7044732 and ABIN7044733) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Astrotactin-1 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RQEKVTDRMDHSK, corresponding to amino acid residues 1068-1080 of mouse Astrotactin-1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234798)

Blocking Peptide: (ABIN7234798)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détail du antigène

Antigène: Astrotactin 1 (ASTN1)

Autre désignation: ASTN1

Sujet:

Synonyms: Astrotactin-1

Description: Astrotactin 1 (ASTN-1) is an integral membrane perforin-like protein known to play a critical role in neurodevelopment. The protein is responsible for the formation of neuron-glial fiber contacts in the cerebellum where it plays an important role in neuronal migration1,2.Astrotactin 1 is also expressed in post-mitotic neuronal precursors of the cerebellum, hippocampus, cerebrum and olfactory bulb. The protein demonstrates an active role in the establishment of laminar structures1.Astrotactin 1 structure reveals a large extracellular C-terminal domain that is complemented by an N-terminal cytosolic domain separated by two transmembrane α-helices1.Studies have found that genetic variations associated with Astrotactin 1 are connected to various neurodevelopmental disorders and other neurological pathologies including Alzheimer's disease1. In addition, ASTN1 null mice exhibit slow migration rates of cerebellar granule cells, smaller cerebellar size and reduced glial neuron binding2 and poorer balance and coordination than wild-type1. Conversely, increased levels of Astrotactin 1 are detected in rat brain following hippocampal injury, linking the protein to repair processes.

ID gène: 11899

NCBI Accession: NM_004319

UniProt: Q61137