BDKRB1 anticorps (3rd Intracellular Loop, C250S)

N° du produit ABIN7042967

L’anticorps anti-BDKRB1 Polyclonal Lapin est utilisé pour la détection de BDKRB1 dans des échantillons de Rat. Il a été validé pour WB, IF, IHC et IC.

Aperçu rapide pour BDKRB1 anticorps (3rd Intracellular Loop, C250S) (ABIN7042967)

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BDKRB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunochromatography (IC)

Classe de qualité: KO Validated

Détail du produit anti-BDKRB1 anticorps

Épitope: 3rd Intracellular Loop, AA 243-257, C250S

Fonction: A Rabbit Polyclonal Antibody to B1 Bradykinin Receptor

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Might not recognize the human epitope.

Homologie: Mouse - 13,15 amino acid residues identical

Attributs du produit: Anti-B1 Bradykinin Receptor (BDKRB1) Antibody (ABIN7042967, ABIN7043940 and ABIN7043941) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize B1R from rat and mouse samples. The antibody may not recognize the receptor from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KEAS RTR*SG GPKGS K, corresponding to amino acid residues 243-257 of rat B1R with replacement of cysteine 250 (C250) with serine (*S)

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:50

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7234868)

Blocking Peptide: (ABIN7234868)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur BDKRB1

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Autre désignation: BDKRB1

Sujet:

Synonyms: B1R, BKR1, B1BKR, BKRB1, Kinin B1, BRADYB1

Description: Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function.1Kinins such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). The desArg9-BK and Lys-desArg9-BK peptides activate BKRB1 while BK and Lys-BK operate by activating BKRB2.2 Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Expression of BKRB1is inducible upon various types of tissue injury and by inflammatory mediators such as bacterial lipopolysaccharide (LPS) and cytokines. BKRB1 was long considered not to be expressed in healthy tissues. However, recent work has demonstrated a low level of expression of BKRB1 in the CNS of rodent and primates. In contrast, BKRB2 is constitutively expressed on various cell types.3 BKRB1 represents a potential therapeutic target for treatment of inflammatory disorders and cardiovascular diseases.

ID gène: 81509

NCBI Accession: NM_000710

UniProt: P97583

Pathways: ACE Inhibitor Pathway