Calcitonin Receptor anticorps (1st Extracellular Loop)

N° du produit ABIN7042978

Cet anticorps Lapin Polyclonal détecte spécifiquement Calcitonin Receptor dans WB, IF, IC et LCI. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour Calcitonin Receptor anticorps (1st Extracellular Loop) (ABIN7042978)

Antigène: Calcitonin Receptor (CALCR)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calcitonin Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-Calcitonin Receptor anticorps

Épitope: 1st Extracellular Loop, AA 201-215

Fonction: A Rabbit Polyclonal Antibody to Calcitonin Receptor

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - 14,15 amino acid residues identical

Attributs du produit: Anti-Calcitonin Receptor (extracellular) Antibody is directed against an epitope of rat CT-R. Anti-Calcitonin Receptor Antibody (ABIN7042978, ABIN7044190 and ABIN7044191) can be used in western blot and live cell imaging applications. It has been designed to recognize CT-R from human, rat and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7234900)

Blocking Peptide: (ABIN7234900)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Calcitonin Receptor

Antigène: Calcitonin Receptor (CALCR)

Autre désignation: CALCR

Sujet:

Synonyms: CALCR, CT receptor, CT-R, C1A/C1B

Description: the calcitonin receptor (CTR) is a class B G-protein coupled receptor (GPCR) that signals via activation of cAMP and protein kinase C (PKC). It is one of 15 human class B GPCRs1,2. Apart from CTR, calcitonin receptor-like receptor (CTLR) is the only other B-class GPCR to bind calcitonin. To date, there are three known human CTR mRNA isoforms arising from alternative splicing3.Calcitonin itself is a peptide hormone that contributes to bone calcification by direct inhibition of osteoclasts which resorb the bony tissue. It is part of a six-member family that has varied functionalities. By binding to receptor activity modifying proteins (RAMPs), CTR and CTLR can form receptors to every member of the calcitonin family. For instance, RAMP1 and CTR construct the calcitonin gene-related peptide (CGRP) receptor.Both CTR and CTLR have seven transmembrane domains, an intracellular C-terminal, and an extracellular N-terminal. To activate the receptors, their N-terminal must first capture the C-terminal of the ligand and then carried to the transmembrane loops where it bestows a conformational change upon them.Besides the bone, CTR has prominent roles in the kidney, CNS, placenta, ovaries, sperm, lung, and in the brain4,5.In osteoclasts, the expression of CTRs declines with age. Interestingly, polymorphism of the CTR gene is strongly associated with decreased fracture-risk in post-menopausal women3,6.

ID gène: 116506

NCBI Accession: NM_001742

UniProt: P32214

Pathways: cAMP Metabolic Process