CDNF anticorps (AA 129-141)

N° du produit ABIN7043031

Cet anticorps anti-CDNF Polyclonal Lapin (ABIN7043031) détecte spécifiquement CDNF dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CDNF anticorps (AA 129-141) (ABIN7043031)

Antigène: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDNF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CDNF anticorps

Épitope: AA 129-141

Fonction: A Rabbit Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor

Réactivité croisée: Humain, Souris

Réactivité croisée (Details): Not recommended for rat samples.

Homologie: Mouse - 10,13 amino acid residues identical

Attributs du produit: Anti-CDNF Antibody is directed against an epitope of human CDNF. Anti-CDNF Antibody (ABIN7043031, ABIN7044785 and ABIN7044786) can be used in western blot and immunohistochemistry applications. It has been designed to recognize CDNF from mouse and human samples. The antibody will not recognize CDNF from rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EKTLDLASVDLRK, corresponding to amino acid residues 129-141 of human CDNF

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:500

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235051)

Blocking Peptide: (ABIN7235051)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CDNF

Antigène: CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))

Autre désignation: CDNF

Sujet:

Synonyms: Cerebral dopamine neurotrophic factor, Arginine-rich mutated in early stage tumors-like 1, ARMET-like protein 1, ARMETL1

Description: Neurotropic factors (NTFs) comprise an important group of secreted proteins regulating the life cycle of neurons during development. NTFs prevent apoptosis and control the number of neurons innervating a target tissue. NTFs also regulate migration, differentiation and maturation of postmitotic neuronal precursors and promote the regeneration of neurons after injury.Cerebral dopamine neurotrophic factor (CDNF) is a member of a sub-family of NTF proteins. The premature form of the protein consists of 187 amino acids while the mature form contains 161 residues. CDNF has a saposin-like N-terminal domain and an unstructured carboxy C-terminal domain with an intradomain cysteine bridge in a CXXC motif. Notably, saposin-like proteins interact with lipids, suggesting that CDNF's N-terminal may also interact with lipids. The saposin-like domain of CDNF crystalizes as a dimer at pH 4.6. It is presumed that CDNF functions upon synthesis and secretion since it does not contain prosequences for enzymatic activation.When CDNF is injected into the striatum of rats after the injection of 6-OHDA (6-OHDA leads to protracted retrograde degeneration of the nigrostriatal pathway) it significantly reduces amphetamine-induced rotational behavior and protects tyrosine hydroxylase (TH) positive dopaminergic cell bodies in the SN and TH-positive fibers in the striatum. In addition, CDNF had showed neurorestorative effects in the same animal model.Currently it is still unknown if CDNF also affects other types of neurons in the CNS or whether it has any effect on the PNS. It is also not clear to which target molecule CDNF binds and what signaling pathways it activates. CDNF might serve as a therapeutic agent for neurodegenerative diseases1.

ID gène: 441549

NCBI Accession: NM_001029954

UniProt: Q49AH0