CasLTR2 anticorps (3rd Extracellular Loop)

N° du produit ABIN7043095

Cet anticorps Lapin Polyclonal détecte spécifiquement CasLTR2 dans WB et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CasLTR2 anticorps (3rd Extracellular Loop) (ABIN7043095)

Antigène: CasLTR2 (CYSLTR2) (Cysteinyl Leukotriene Receptor 2 (CYSLTR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CasLTR2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-CasLTR2 anticorps

Épitope: 3rd Extracellular Loop, AA 270-284

Fonction: A Rabbit Polyclonal Antibody to Human CysLTR2

Réactivité croisée (Details): Not recommended for use with rat and mouse samples.

Homologie: Human only

Attributs du produit: Anti-Human CysLTR2 (extracellular) Antibody (ABIN7043095 and ABIN7044560) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect live cell flow cytometry applications. It has been designed to recognize CysLTR2 from human samples only.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HLTTWKVGL(S)KDRLH, corresponding to amino acid residues 270-284 of human CysLTR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CasLTR2

Antigène: CasLTR2 (CYSLTR2) (Cysteinyl Leukotriene Receptor 2 (CYSLTR2))

Autre désignation: CYSLTR2

Sujet:

Synonyms: CYSLT2, Cysteinyl leukotriene receptor 2, hGPCR21, G-protein coupled receptor HG57

Description: LTC4, LTD4, and LTE4 are cysteinyl leukotrienes (cys-LTs) peptide conjugated lipids derived from arachidonic acid as a result of immune or inflammatory stimuli1-3.The above mentioned cys-LTs bind and activate two receptors belonging to the G-protein coupled receptor superfamily, CysLTR1 and CysLTR2 (also named cysLT1 and cysLT2 respectively). There is evidence though that other receptors are yet to be identified4. These two receptors couple to both pertussis toxin sensitive (Gi/o) and insensitive (Gq, which initiates Ca2+ influx) G-proteins for their signaling. The G-protein coupled to is probably determined by which ligand binds the receptor as all three cys-LTs can activate the two receptors albeit with different affinities5. In mouse, CysLTR1 and CysLTR2 are subject to alternative splicing. CysLTR1 receptor expresses greater affinity for LTD4 and binds equally to LTC4 and LTE4whereas CysLTR2 has greater and equal affinity towards LTC4 and LTD4 over LTE45.Human CysLTR1 is highly expressed in spleen, peripheral blood, leukocytes. It is less strongly expressed in lung, small intestine, pancreas and hardly or not expressed in liver, colon, kidney, skeletal muscle, testis heart and brain4. On the other hand, CysLTR2 is highly expressed in spleen and leukocytes. Its expression in the heart, brain, spinal cord and adrenal gland differs it from that of CysLTR14.Cys-LTs and their receptors are involved in respiratory diseases like asthma and other conditions such as cancer cardiovascular, gastrointestinal, skin and immune disorders1,6.

ID gène: 57105

NCBI Accession: NM_001308465

UniProt: Q9NS75