DPYSL2 anticorps (Intracellular)

N° du produit ABIN7886523

Cet anticorps anti-DPYSL2 Polyclonal Lapin (ABIN7886523) détecte spécifiquement DPYSL2 dans WB et IHC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour DPYSL2 anticorps (Intracellular) (ABIN7886523)

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYSL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-DPYSL2 anticorps

Épitope: AA 504-517, Intracellular

Fonction: A Rabbit Polyclonal Antibody to CRMP-2

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-CRMP2 Antibody (ABIN7043097, ABIN7044542 and ABIN7044543) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CEVSVTPKTVTPAS, corresponding to amino acid residues 504-517 of rat CRMP2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235204)

Blocking Peptide: (ABIN7235204)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur DPYSL2

Antigène: DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))

Autre désignation: DPYSL2

Sujet:

Synonyms: CRMP-2, Collapsin response mediator protein 2, Dihydropyrimidinase-related protein 2, DHPRP2, DRP-2, Dpysl2, Turned on after division 64 kDa protein, TOAD-64, Ulip2, Unc-33-like phosphoprotein 2

Description: Collapsin response mediator protein 2 (CRMP-2, DRP-2), is a kinesin-binding protein and a member of the CRMP family, a novel family of microtubule-associated proteins (MAPs). This family consists of 5 highly conserved phosphorylated proteins: CRMP1-CRMP5. CRMP-2 was originally identified in the regulation of microtubule dimerization. CRMP-2 is the first member of the CRMP family identified in primary neuronal cells1,2.Physiological functions of CRMP-2 protein include regulation of cell surface receptor endocytosis, kinesin-dependent axonal transport, growth cone collapse, polarity and differentiation of developing neurons and neurite outgrowth and the regulation of microtubule dynamics2.Studies suggest that CRMP-2 can modulate neuronal viability through the PI3K/mTOR/S6K pathway. In addition, CRMP-2 expression has been detected in non-neuronal cells such as leukocytes, fibroblasts and neuroblastoma1.Phosphorylation of CRMP-2 on specific Thr and Ser residues inactivates its activity, leading to inhibition of axonal growth and neuronal polarity. Knockdown of CRMP-2 shortens the total dendritic length and decreases dendritic branching3.

ID gène: 25416

NCBI Accession: NM_001386

UniProt: P47942

Pathways: Regulation of Cell Size