DPP10 anticorps (C-Term, Extracellular)

N° du produit ABIN7043099

L’anticorps anti-DPP10 Polyclonal Lapin est utilisé pour la détection de DPP10 dans des échantillons de Rat. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour DPP10 anticorps (C-Term, Extracellular) (ABIN7043099)

Antigène: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPP10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-DPP10 anticorps

Épitope: AA 356-370, C-Term, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Dipeptidyl Peptidase 10

Réactivité croisée: Humain, Souris, Rat

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Attributs du produit: Anti-DPP10 (extracellular) Antibody (ABIN7043099, ABIN7045044 and ABIN7045045) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize DPP10 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CSRKYEMTSDTWISK, corresponding to amino acid residues 356-370 of rat DPP10

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IP

Negative Control: (ABIN7235212)

Blocking Peptide: (ABIN7235212)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur DPP10

Antigène: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Autre désignation: DPP10

Sujet:

Synonyms: Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase X, DPP X, DPPY, DPL2, DPRP3

Description: Dipeptidyl peptidase 10 (DPP10, DPPY) is a member of the prolyl oligopeptidase family (shares a 30 % sequence identity with DPP4) and belongs to the S9B serine protease subfamily. DPP10 is a homologous glycosylated, single-pass type II transmembrane protein that lacks the crucial serine residue of the catalytic triad. Unlike other KV4 subunits such as DPP6, DPP10 has a restricted expression pattern including the brain, adrenal gland and pancreas. The presence of DPP10 in endocrine cells suggests that the protein may also have an additional function related to the regulation of hormone secretion. DPP10 accelerates the activation and inactivation of KV4.3 channel gating with distinct biophysical properties.DPP10 associates with the α-subunits of the KV4 subfamily to form a ternary complex of approximately 750 kDa1. In addition, DPP10 forms complexes with other auxiliary subunits of the KV4 channels. In dorsal root ganglion DPP10 is co-localized with K+ channel-interacting proteins 1 and 2 (KChIPs) in the somatic surface and cytoplasm of KV4.3 nociceptors. Recently it has been hypothesized that KV4/KChIP/DPPL ternary complexes exist in subthreshold A-type K+ currents (Isas) expressing nociceptors and pain-modulating spinal interneurons2.DPP10 has been implicated in various pathologies. Aggregation of the protein is associated with neurodegenerative conditions such as Alzheimer's, diffuse Lewy body disease and fronto-temporal dementia3.

ID gène: 363972

NCBI Accession: NM_020868

UniProt: Q6Q629