DLG1 anticorps (L27 Domain, N-Term)

N° du produit ABIN7043101

Cet anticorps Lapin Polyclonal détecte spécifiquement DLG1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour DLG1 anticorps (L27 Domain, N-Term) (ABIN7043101)

Antigène: DLG1 (Discs, Large Homolog 1 (DLG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DLG1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DLG1 anticorps

Épitope: AA 17-31, L27 Domain, N-Term

Fonction: A Rabbit Polyclonal Antibody to SAP-97

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse - identical

Attributs du produit: Anti-/DLG1 Antibody is directed against an epitope of human . Anti-/DLG1 Antibody (ABIN7043101, ABIN7045150 and ABIN7045151) can be used in western blot analysis. It has been designed to recognize from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235220)

Blocking Peptide: (ABIN7235220)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur DLG1

Antigène: DLG1 (Discs, Large Homolog 1 (DLG1))

Autre désignation: DLG1

Sujet:

Synonyms: Synapse-associated protein 97, Discs large homolog 1

Description: SAP-97 belongs to the MAGUK (membrane associated guanylate kinase) homologs along with PSD-95, PSD-93 and SAP102.Like other members, SAP-97 has three PDZ domains, one SH3 domain and an inactive GUK domain. Alternative splicing of SAP-97 gives to a number of different isoforms thereby complicating the understanding of its roles1.In the post-synaptic cell, SAP-97 is the only MAGUK to directly interact with the GluA1 AMPA receptor2. SAP-97 also directly interacts with NMDA receptors through the PDZ domain3,4.SAP-97 was shown to interact with KV1.45 and with KV4.2 where it directs the channel to spines in hippocampal neurons6. It can also interact with the channel in the heart7.Interactions with Kir channels have also been observed8,9.Thus, SAP-97 serves as a regulator of neuronal excitability and synaptic function. Roles for the protein in schizophrenia, Alzheimer's and Parkinson's disease and epilepsy have been found1.

ID gène: 1739

NCBI Accession: NM_004087

UniProt: Q12959

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response