GPR17 anticorps (Intracellular)

N° du produit ABIN7043149

Cet anticorps Lapin Polyclonal détecte spécifiquement GPR17 dans WB, IHC et IF. Il présente une réactivité envers Rat.

Aperçu rapide pour GPR17 anticorps (Intracellular) (ABIN7043149)

Antigène: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR17 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GPR17 anticorps

Épitope: AA 220-232, Intracellular

Fonction: A Rabbit Polyclonal Antibody to GPR17 Receptor

Specificité: Intracellular, 3rd loop

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Not recommended for human samples.

Homologie: Mouse - identical

Attributs du produit: Anti-GPR17 Antibody (ABIN7043149, ABIN7044435 and ABIN7044436) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR17 from rat and mouse samples. It is unlikely to recognize the protein from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RQGPRIEKHLKNK, corresponding to amino acid residues 220-232 of rat GPR17

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7235376)

Blocking Peptide: (ABIN7235376)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur GPR17

Antigène: GPR17 (G Protein-Coupled Receptor 17 (GPR17))

Autre désignation: GPR17

Sujet: G-protein coupled receptor 17, Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT Receptor, P2Y-like receptor,GPR17 is an orphan receptor that can be double-activated by uracil and cysteinyl-leukotriene (CysLT). It is phylogenetically related to both purinergic P2Y and CysLT receptors. GPR17 belongs to the superfamily of G-protein coupled receptors (GPCRs)4.GPR17 expression is highly detected in the brain, kidney, and heart. In the brain, GPR17 is mainly distributed in white matter, gray matter, subependymal zone, and corpus callosum1.Studies have shown that GPR17 receptor plays an important role in spinal cord injury, myelin sheath injury, cerebral ischemic injury, where its expression is extremely upregulated1,2.GPR17 activation promotes oligodendrocyte differentiation and progression toward mature myelin-forming cells. Thus, GPR17 modulators may be used as therapeutic tools to treat pathologies associated with myelin repair in CNS demyelinating diseases3.

Alternative names: GPR17, G-protein coupled receptor 17, Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT Receptor, P2Y-like receptor

ID gène: 767613

NCBI Accession: NM_001161415

UniProt: Q09QM4