GFRA3 anticorps (Extracellular, N-Term)

N° du produit ABIN7043212

Cet anticorps Lapin Polyclonal détecte spécifiquement GFRA3 dans WB. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour GFRA3 anticorps (Extracellular, N-Term) (ABIN7043212)

Antigène: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GFRA3 anticorps

Épitope: AA 172-185, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to GDNF Family Receptor α3

Réactivité croisée: Souris, Rat

Homologie: Mouse,rat,human - 13,14 amino acid residues identical

Attributs du produit: Anti-GFR alpha 3 (extracellular) Antibody (ABIN7043212, ABIN7044779 and ABIN7044780) is a highly specific antibody directed against an epitope of mouse GDNF receptor α3. The antibody can be used in western blot analysis. It has been designed to recognize GFR α3 from human, mouse, and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CDRLRKAYGEA(S)SG, corresponding to amino acid residues 172-185 of mouse GFRA3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235580)

Blocking Peptide: (ABIN7235580)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GFRA3

Antigène: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Autre désignation: GFRA3

Sujet:

Synonyms: GFRA3, GFRα3, GDNF family receptor α3, GDNF receptor alpha 3

Description: GFRα3 (GDNF Family Receptor α3) belongs to the glial cell line derived neurotrophic factor (GDNF) family of receptors which contains four members GFRα1-4. The GDNF family of ligands (GFLs)- GDNF, Neurturin, Artemin, and Persephin bind to co-receptors GFRα1-4 and activate Ret receptor tyrosine kinase. GDNF-family receptor α is glycosyl-phosphatidylinositol anchored to the cell surface. GFRα3 structure contains three homologous domains (D1, D2 and D3) and a C-terminal extension1-4.GFRα3 is a highly selective receptor for Artemin (Artn). Artemin is a vasculature-derived neurotrophic factor that modulates the development and function of sensory neurons and participates in the pathophysiology of peripheral inflammation and pain hyperalgesia.In adults, GFRα3 is restricted to neurons of the peripheral nervous system. The protein is expressed by a subpopulation of nociceptive sensory neurons which also express the Ret receptor tyrosine kinase, TRPV1, TRPA11,2,3.

ID gène: 14587

NCBI Accession: NM_001496

UniProt: O35118