GRIP1 anticorps (C-Term, Intracellular)

N° du produit ABIN7043227

Cet anticorps Lapin Polyclonal détecte spécifiquement GRIP1 dans WB. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour GRIP1 anticorps (C-Term, Intracellular) (ABIN7043227)

Antigène: GRIP1 (Glutamate Receptor Interacting Protein 1 (GRIP1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GRIP1 anticorps

Épitope: AA 963-977, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to GRIP1

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-GRIP1 Antibody (ABIN7043227, ABIN7045158 and ABIN7045159) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize GRIP1 from human, mouse, and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RKSVTLRKMKQEIKE, corresponding to amino acid residues 963-977 of rat GRIP1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235622)

Blocking Peptide: (ABIN7235622)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GRIP1

Antigène: GRIP1 (Glutamate Receptor Interacting Protein 1 (GRIP1))

Autre désignation: GRIP1

Sujet:

Synonyms: Glutamate receptor interacting protein 1

Description: GRIP1 (glutamate receptor interacting protein 1) is a neuron-enriched scaffolding protein that plays an important role in regulating synaptic trafficking, synaptic strength and synaptic organization and transmission of AMPA receptor 2 and 3 (GluA2/3) 1,2. GRIP1 structure contains 7 PDZ domains responsible for protein-protein interactions. GRIP1 forms homodimers that can bind and simultaneously organize and assemble protein complexes via PDZ domains1,2.GRIP1 is abundantly expressed in glutamatergic and GABAergic synapses. In addition, GRIP1 expression can be found in muscle cells and in the epidermis1,3. Studies on GRIP1 knockout mice have revealed multi-organ developmental abnormalities. These mice die due to hemorrhage and hypovolemia in the embryonic or early post-natal period2.Mutations in GRIP1 protein resulting in a gain-of-function phenotype are linked to autism, while neuronal-specific loss-of-function mice have prosocial behavior. Other point mutations have been associated with schizophrenia and congenital kidney disease2,3.

ID gène: 84016

NCBI Accession: NM_001178074

UniProt: P97879

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway