Metabotropic Glutamate Receptor 4 anticorps (Extracellular)

N° du produit ABIN7043249

L’anticorps Lapin Polyclonal anti-Metabotropic Glutamate Receptor 4 a été validé pour WB, IF, IC et LCI. Il convient pour détecter Metabotropic Glutamate Receptor 4 dans des échantillons de Rat.

Aperçu rapide pour Metabotropic Glutamate Receptor 4 anticorps (Extracellular) (ABIN7043249)

Antigène: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-Metabotropic Glutamate Receptor 4 anticorps

Épitope: AA 33-44, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 4

Specificité: Extracellular, N-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-mGluR4 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR4. Anti-mGluR4 (extracellular) Antibody (ABIN7043249, ABIN7044344 and ABIN7044345) can be used in western blot and live cell imaging applications. It has been designed to recognize mGluR4 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: KPKGHPHMNSIR(C), corresponding to amino acid residues 33-44 of rat mGluR4

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7235693)

Blocking Peptide: (ABIN7235693)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur Metabotropic Glutamate Receptor 4

Antigène: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Autre désignation: GRM4

Sujet: Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D,Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi1.The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translational modifications like phosphorylation as well as protein-protein interactions. The C-terminal region is also subject to alternative splicing2.mGluR4 is predominantly expressed presynaptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR43,4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or unami)2,4.mGluR4 knock out mice display impaired cerebellar synaptic plasticity as well as some learning disabilities5. In addition, this receptor has emerged as a target for the treatment of Parkinson's disease6.

Alternative names: mGluR4, Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D

ID gène: 24417

NCBI Accession: NM_000841

UniProt: P31423