GNRHR anticorps (Extracellular, N-Term)

N° du produit ABIN7043262

Cet anticorps anti-GNRHR Polyclonal Lapin (ABIN7043262) détecte spécifiquement GNRHR dans WB, IF, FACS, IHC et LCI. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour GNRHR anticorps (Extracellular, N-Term) (ABIN7043262)

Antigène: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GNRHR est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Détail du produit anti-GNRHR anticorps

Épitope: AA 3-13, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to GnRH Receptor

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Not recommended for use with human samples.

Homologie: Mouse - identical

Attributs du produit: Anti-GnRH Receptor (extracellular) Antibody (ABIN7043262 and ABIN7044416) is a highly specific antibody directed against an epitope of rat GnRHR. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope, and can potentially be used for detecting the protein in living cells. It has been designed to recognize GnRHR from mouse and rat samples. It is not suited to recognize GnRHR from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)NNASLEQDQNH, corresponding to amino acid residues 3-13 of rat GnRHR

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7235732)

Blocking Peptide: (ABIN7235732)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GNRHR

Antigène: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Autre désignation: GnRHR

Sujet:

Synonyms: Gonadotropin-releasing hormone receptor, GnRHR, Leutinizing hormone releasing hormone receptor, LHRHR, Luliberin receptor

Description: Gonadotropin-releasing hormone (GnRH) or Luteinizing hormone releasing hormone (LHRH) is a decapeptide synthesized and released from neurons in the hypothalamus and stimulates the synthesis and release of gonadotropin hormone (or luteinizing hormone) and follicle stimulating hormone from the pituitary gland1. GnRH is expressed as various variants, and most vertebrates express more than one form of GnRH1-3.GnRH and its variants bind and activate GnRH receptor (GnRHR), a member of the G-protein coupled receptor (GPCR) superfamily. Three forms of the receptor have been identified in vertebrates (types I, II and III). Like all members, GnRHR has seven transmembrane domains and an extracellular N-terminus and an intracellular C-terminal tail. The receptor also has a number of glycosylation sites in its extracellular loops. In addition, the C-terminal tail is unusually short and lacks consensus sites known to undergo post-translational modifications like phosphorylation. In consequence, this affects the receptor's desensitization and internalization4.Expression of GnRHR is detected in the gonadotrope and various tissues like the breast, gonads, prostate and uterus4,5.

ID gène: 81668

NCBI Accession: NM_001083111

UniProt: P30969