LPAR5 anticorps (3rd Extracellular Loop)

N° du produit ABIN7043316

Cet anticorps anti-LPAR5 Polyclonal Lapin (ABIN7043316) détecte spécifiquement LPAR5 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour LPAR5 anticorps (3rd Extracellular Loop) (ABIN7043316)

Antigène: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LPAR5 anticorps

Épitope: 3rd Extracellular Loop, AA 261-276

Fonction: A Rabbit Polyclonal Antibody to LPA Receptor 5

Réactivité croisée (Details): Will not recognize rat or mouse LPA5 receptor.

Homologie: Mouse,Rat - not recommended for use with mouse,rat samples

Attributs du produit: Anti-Human LPAR5 (extracellular) Antibody is directed against an epitope of the human LPA5 receptor. Anti-Human LPAR5 (extracellular) Antibody (ABIN7043316, ABIN7044574 and ABIN7044575) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize LPA5 receptor from human samples only.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RSKLVAASVPARDRVR, corresponding to amino acid residues 261-276 of human LPA5 receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur LPAR5

Antigène: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Autre désignation: LPAR5

Sujet:

Synonyms: Lysophosphatidic acid receptor 5, LPA-5, GPR92, GPR93

Description: LPA (lysophosphatidic acid) mediates cellular differentiation, growth, survival and motility through two subgroups of G-protein coupled receptors (GPCRs): The Edg (endothelial differentiation gene) family - LPA1, LPA2, LPA3 and the non-Edg family - LPA4, LPA5, LPA61.Like all GPCRs, LPA receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail1.Alkyl-LPA, commonly found in platelets activates LPA5, thus explaining the high expression of the receptor in platelets2. LPA is expressed in astrocytes, and sensory and motor neurons in the spinal cord. It is also detected in spleen, heart, placenta, lliver and colon3.LPA5 activation leads to cAMP production, however, it does so in a Gs independent manner4,5. The receptor couples Gq, thus leading to Ca2+ mobilization4.Activation of LPA5 was also shown to initiate neuropathic pain in mouse models. LPA5 knockout mice do not develop neuropathic pain6.

ID gène: 57121

NCBI Accession: NM_020400

UniProt: Q9H1C0