LPAR6 anticorps (2nd Extracellular Loop)

N° du produit ABIN7043317

Cet anticorps Lapin Polyclonal détecte spécifiquement LPAR6 dans WB, FACS et LCI. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour LPAR6 anticorps (2nd Extracellular Loop) (ABIN7043317)

Antigène: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR6 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-LPAR6 anticorps

Épitope: 2nd Extracellular Loop, AA 156-168

Fonction: A Rabbit Polyclonal Antibody to LPA Receptor 6 (P2RY5)

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse -12,13 amino acid residues identical

Attributs du produit: Anti-LPAR6 (P2RY5) (extracellular) Antibody is directed against an epitope of the human LPA receptor 6. Anti-LPAR6 (P2RY5) (extracellular) Antibody (ABIN7043317, ABIN7044576 and ABIN7044577) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize LPA receptor 6 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: STHSQGNNASEAC, corresponding to amino acid residues 156-168 of human LPA receptor 6

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235906)

Blocking Peptide: (ABIN7235906)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur LPAR6

Antigène: LPAR6 (Lysophosphatidic Acid Receptor 6 (LPAR6))

Autre désignation: LPAR6

Sujet:

Synonyms: Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, P2Y purinoceptor 5, Purinergic receptor 5, P2Y5, RB intron encoded G-protein coupled receptor

Description: Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol-3-phosphate) is a bioactive lipid molecule with a phosphate, a glycerol, and a fatty acid in its structure. The cellular effects of LPA include proliferation, migration, cytokine secretion, and morphological change. These pleiotropic actions allow LPA to participate in a wide variety of biological processes, such as brain development, oncogenesis, wound healing and cancer progression1. To date, at least 6 subtypes of LPA receptor have been identified. The LPA1-3 receptors are members of the endothelial cell differentiation gene (Edg) family2.LPA6 (P2Y5) was cloned as an orphan GPCR and is closely related to the fourth lysophosphatidic acid receptor, LPA43. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N terminus is on the extracellular side of the membrane, and the C terminus is on the cytoplasmic side4.LPA6 mRNA is expressed ubiquitously including in skin and hair follicle cells.A recent study suggested that LPA6 is essential for human hair growth. A loss of function is not compensated for, and ultimately leads to pathological changes and hair loss5.

ID gène: 10161

NCBI Accession: NM_005767

UniProt: P43657