MRGPRE anticorps (3rd Intracellular Loop)

N° du produit ABIN7043319

Cet anticorps anti-MRGPRE Polyclonal Lapin (ABIN7043319) détecte spécifiquement MRGPRE dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour MRGPRE anticorps (3rd Intracellular Loop) (ABIN7043319)

Antigène: MRGPRE (MAS-Related GPR, Member E (MRGPRE))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRGPRE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MRGPRE anticorps

Épitope: 3rd Intracellular Loop, AA 197-209

Fonction: A Rabbit Polyclonal Antibody to MRGPRE Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical, human - 10,13 amino acid residues identical

Attributs du produit: Anti-MRGPRE Antibody (ABIN7043319, ABIN7044604 and ABIN7044605) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize MRGPRE from rat, human, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RVERGPERHQPRG, corresponding to amino acid residues 197 - 209 of rat MRGPRE

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235909)

Blocking Peptide: (ABIN7235909)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur MRGPRE

Antigène: MRGPRE (MAS-Related GPR, Member E (MRGPRE))

Autre désignation: MRGPRE

Sujet:

Synonyms: Mas-related G-protein coupled receptor member E, GPCR MRGE, GPR167

Description: The Mas-related G protein-coupled receptors (MRGPRs), formerly called Mas-related genes (MRGs) includes nine members: MrgprA, B, C, D, E, F, G, H, and the primate-specific MRGPRX1,2.MRGPRE consist of only one receptor per species and is conserved in rodents and primates2. MRGPRE structure contains a Cys-Cys bridge from transmembrane domain (TM) 3, an "ionic-lock" known to inhibit activation and activity in some class A GPCRs1,2.Human and mouse MRGPRE is highly expressed in neurons of the brain and mast cells. Transcripts are also found in medium and large diameter neurons of human dorsal root ganglia (DRG) sections and in other areas of the central nervous system, including cerebral cortex, hippocampus, spinal cord, and cerebellum. MRGPRE was also found in human, mouse, and rat placenta tissue and in enteric neurons1,2.Mouse lacking the MRGPRE protein showed decreased nociceptive behavior and significant deficits in the induction of mechanical allodynia after chronic constriction injury2.

ID gène: 404660

NCBI Accession: NM_001039165

UniProt: Q7TN40