NMUR2 anticorps (Extracellular, N-Term)

N° du produit ABIN7043366

L’anticorps anti-NMUR2 Polyclonal Lapin est utilisé pour la détection de NMUR2 dans des échantillons de Rat. Il a été validé pour WB, IHC, IC, IF et LCI.

Aperçu rapide pour NMUR2 anticorps (Extracellular, N-Term) (ABIN7043366)

Antigène: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMUR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)

Détail du produit anti-NMUR2 anticorps

Épitope: AA 3-16, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuromedin-U Receptor 2

Réactivité croisée: Humain, Souris, Rat

Homologie: 14 amino acid residues identical,Mouse -13, human - 7

Attributs du produit: Anti-NMUR2 (extracellular) Antibody (ABIN7043366, ABIN7044706 and ABIN7044707) is a highly specific antibody directed against an epitope of the rat Neuromedin-U receptor 2. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize NMUR2 from rat, human, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KLENASWIHDPLMK, corresponding to amino acid residues 3-16 of rat NMUR2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236067)

Blocking Peptide: (ABIN7236067)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NMUR2

Antigène: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Autre désignation: NMUR2

Sujet:

Synonyms: Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72

Description: Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1 (NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A GPCR family and share about 50 % identity with each other in the seven transmembrane region.NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5.Central effects of NMU, including the regulation of food intake, energy balance, stress response, and nociception, are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 has been suggested as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5.Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2.

ID gène: 64042

NCBI Accession: NM_020167

UniProt: Q9ESQ4

Pathways: Feeding Behaviour