NPY1R anticorps (AA 237-252)

N° du produit ABIN7043371

Cet anticorps Lapin Polyclonal détecte spécifiquement NPY1R dans WB, IHC, IF et IC. Il présente une réactivité envers Humain.

Aperçu rapide pour NPY1R anticorps (AA 237-252) (ABIN7043371)

Antigène: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPY1R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Détail du produit anti-NPY1R anticorps

Épitope: AA 237-252

Fonction: A Rabbit Polyclonal Antibody to Neuropeptide Y1 Receptor

Specificité: 3rd intracellular loop

Réactivité croisée: Humain, Rat

Homologie: Rat,mouse - 14,16 amino acid residues identical

Attributs du produit: Anti-NPY1R Antibody is directed against an intracellular epitope of the human neuopeptide Y1 receptor (NPY1R). Anti-NPY1R Antibody (ABIN7043371, ABIN7044668 and ABIN7044669) can be used in western blot analysis, immunohistochemistry, and immunocytochemical applications. It has been designed to recognize NPY1R from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RLKRRNNMMDKMRDNK, corresponding to amino acid residues 237-252 of human NPY1R

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Cited Application: IHC|ICC

Negative Control: (ABIN7236086)

Blocking Peptide: (ABIN7236086)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur NPY1R

Antigène: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Autre désignation: NPY1R

Sujet: Neuropeptide Y1 receptor, Neuropeptide Y receptor type 1, NPYR, NPYY1,Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with the peptide YY (PYY) and the pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R) and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2 The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2NPY1R is considered to be a postsynaptic receptor. In the CNS, NPY1Rs are concentrated in the cortical areas of the brain, cerebral cortex, olfactory nucleus, hippocampus, hypothalamic nuclei, and thalamic nuclei.4 In addition, this receptor has a bimodal role in the immune system, serving as a strong negative regulator on T cells as well as a key activator of antigen-presenting cell function.5

Alternative names: NPY1R, Neuropeptide Y1 receptor, Neuropeptide Y receptor type 1, NPYR, NPYY1

ID gène: 4886

NCBI Accession: NM_000909

UniProt: P25929

Pathways: Negative Regulation of Hormone Secretion, Feeding Behaviour