NPY4R anticorps (C-Term, Intracellular)

N° du produit ABIN7043374

Cet anticorps Lapin Polyclonal détecte spécifiquement NPY4R dans WB, IHC, IC et IF. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour NPY4R anticorps (C-Term, Intracellular) (ABIN7043374)

Antigène: NPY4R (Neuropeptide Y Receptor Y4 (NPY4R))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPY4R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF)

Détail du produit anti-NPY4R anticorps

Épitope: AA 326-340, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Neuropeptide Y4 Receptor

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - 13,15 amino acid residues identical

Attributs du produit: Anti-NPY4R Antibody is directed against an epitope of the rat neuropeptide Y4 receptor (NPY4R). Anti-NPY4R Antibody (ABIN7043374 and ABIN7044672) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize NPY4R from human, rat, and mouse samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: NINFKKDIKALVLTC corresponding to amino acid residues 326-340 of rat NPY4R

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7236098)

Blocking Peptide: (ABIN7236098)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NPY4R

Antigène: NPY4R (Neuropeptide Y Receptor Y4 (NPY4R))

Autre désignation: NPY4R

Sujet:

Synonyms: Neuropeptide Y4 receptor, Neuropeptide Y receptor type 4, Pancreatic polypeptide receptor 1, PPYR1

Description: Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, along with peptide YY (PYY) and pancreatic polypeptide (PP). NPY is involved in the regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R), and Y6 (NPY6R).2 Four of these (Y1, Y2, Y4, and Y5) are expressed in humans.2The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on their high frequency and density in steroid hormone-producing tumors, the NPYRs might be of potential use in tumor management.2NPY4R preferentially binds PP, while NPY1R, NPY2R, and NPY5R bind both NPY and PP.NPY1R, NPY2R, and NPY5R share a low degree of identity (27-31 % overall). NPY4R is more similar to NPY1R, displaying an overall identity of 43-53 %.4Human NPY4R (also named pancreatic polypeptide receptor 1) mRNA is highly expressed in the small and large intestines and the prostate. Tissue distribution studies in human and mouse suggest potential roles for NPY4R in the gastrointestinal tract, heart, and prostate, as well as in neural and endocrine signaling. Only low levels of NPY4R expression in various areas of brain were displayed.5

ID gène: 29471

NCBI Accession: NM_005972

UniProt: Q63447