NRP2 anticorps (Extracellular)

N° du produit ABIN7043380

Cet anticorps Lapin Polyclonal détecte spécifiquement NRP2 dans WB, IHC, IF et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour NRP2 anticorps (Extracellular) (ABIN7043380)

Antigène: NRP2 (Neuropilin 2 (NRP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NRP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-NRP2 anticorps

Épitope: AA 747-758, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Neuropilin-2

Specificité: Extracellular, N-terminus

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse - 11,12 amino acid residues identical

Attributs du produit: Anti-Neuropilin-2 (NRP2) (extracellular) Antibody (ABIN7043380, ABIN7044700 and ABIN7044701) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize NRP2 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)REDQGGEWKHGR, corresponding to amino acid residues 747-758 of human neuropilin-2

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7236118)

Blocking Peptide: (ABIN7236118)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur NRP2

Antigène: NRP2 (Neuropilin 2 (NRP2))

Autre désignation: NRP2

Sujet: Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2,The neuropilins (NRPs) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, and physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin co-receptors with plexins, as well as enhancers of cellular responses to members of the vascular endothelial growth factor (VEGF) family.The NRP family comprises two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2), which are usually expressed as homodimers but can also appear as heterodimers. NRP2 contains a large extracellular N-terminal which consists of five domains, a short transmembrane domain and a small cytoplasmic domain1-3. NRP2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. NRP2 has been shown to mediate proliferation, survival, and migration of tumor cells3.NRP2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous systems2.

Alternative names: Neuropilin-2 (NRP2), Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2

ID gène: 8828

NCBI Accession: NM_003872

UniProt: O60462

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals